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Five serogroups cause the majority of meningococcal disease worldwide: A, B, C, W-135 and Y[1].
About Novartis
Novartis Vaccines and Diagnostics is a division of Novartis focused on the development of preventive treatments.
Novartis AG provides healthcare solutions that address the evolving needs of patients and societies. AEOL 10150 is under development as a countermeasure for nuclear and radiological exposure and as a protective agent in cancer patients receiving radiation therapy.
“AEOL 10150 has consistently shown a protective effect against the harmful effects in radiation, including when the drug is administered up to 72 hours after exposure,” stated Zeljko Vujaskovic, M. Research has shown that ROS and RNS have important cell signaling roles, and through its interaction with RNS and ROS, AEOL 10150 appears to have multiple mechanisms of action including anti-oxidant, anti-inflammatory and anti-angiogenic activities.
-- Large scale manufacturing – Aeolus has contract capacity with a large manufacturing site to mass produce large quantities of AEOL 10150 under GMP conditions.
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Novartis Vaccines is the world's fifth-largest vaccines manufacturer and second-largest supplier of flu vaccines in the US.2 billion was invested in R&D activities throughout the Group. [5. Additionally, mice receiving AEOL 10150 experienced a reversal in weight loss seen in the untreated mice. Ph. Additionally, based on its mechanism, it is believed that the compound may potentially protect against exposure to chlorine gas.
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