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Because invasive meningococcal disease can progress so rapidly, high levels of circulating antibodies are critical for protection.
Five serogroups cause the majority of meningococcal disease worldwide: A, B, C, W-135 and Y[1].2 billion. Epidemiology and Prevention of Vaccine-Preventable Diseases (The Pink Book: Course Textbook).] Novartis Vaccines and Diagnostics, Scientific Platform: Meningococcal Diseases, Revised December 11, 2008 [4.] World Health Organization.
-- Multiple Applications – AEOL 10150 has demonstrated protective effects against radiation and mustard gas exposure, and within these indications has shown the ability to treat multiple organ systems.
About Aeolus Pharmaceuticals
Aeolus is developing a variety of therapeutic agents based on its proprietary small molecule catalytic antioxidants, with AEOL 10150 being the first to enter human clinical evaluation. AEOL 10150 is a patented, small molecule catalytic antioxidant that mimics and thereby amplifies the body's natural enzymatic systems for eliminating reactive oxygen species, or free radicals.
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The BLA was submitted on August 28, 2008 for use of Menveo in subjects age 11 - 55. In addition to Menveo, Novartis Vaccines is developing a recombinant vaccine for its potential to provide broad coverage against multiple strains of serogroup B, for which no vaccine is currently available. The company has already distributed more than 26 million doses of Menjugate around the world and produced MenZB, a vaccine against a strain of meningococcus B specific to a recent outbreak in New Zealand.
About Novartis
Novartis Vaccines and Diagnostics is a division of Novartis focused on the development of preventive treatments.] Centers for Disease Control and Prevention.
Data to Be Presented at the 55th Annual Meeting of the Radiation Research Society in October
MISSION VIEJO, Calif. Additionally, mice receiving AEOL 10150 experienced a reversal in weight loss seen in the untreated mice. The product also has an established stability profile that permits long-term storage.
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