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For more information, please visit www.meningitis. Ph.D.
“AEOL 10150 has consistently shown a protective effect against the harmful effects in radiation, including when the drug is administered up to 72 hours after exposure,” stated Zeljko Vujaskovic, M. Research has shown that ROS and RNS have important cell signaling roles, and through its interaction with RNS and ROS, AEOL 10150 appears to have multiple mechanisms of action including anti-oxidant, anti-inflammatory and anti-angiogenic activities. The product also has an established stability profile that permits long-term storage.
-- Large scale manufacturing – Aeolus has contract capacity with a large manufacturing site to mass produce large quantities of AEOL 10150 under GMP conditions. Additionally, based on its mechanism, it is believed that the compound may potentially protect against exposure to chlorine gas. Important factors that could cause results to differ include risks associated with uncertainties of progress and timing of clinical trials, scientific research and product development activities, difficulties or delays in development, testing, obtaining regulatory approval, the need to obtain funding for pre-clinical and clinical trials and operations, the scope and validity of intellectual property protection for Aeolus' product candidates, proprietary technologies and their uses, and competition from other biopharmaceutical companies.
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Novartis is the only company with leading positions in these areas. MMWR 2005; 54 (RR07): 1-21.D. Specific data related to this study will be presented by Dr.D. Ph. Our objective now is to determine how long after exposure we can administer the drug and achieve significant benefits and to more clearly identify the appropriate dose and dosing regimen. Doses in the range of 5 to 10 mg/kg/d showed a more potent effect including more significant mitigation as assessed by histopathology and immunohistochemistry.
“AEOL 10150 continues to demonstrate significant, protective effects when administered after exposure to radiation,” stated John L.
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