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"Meningococcal disease is a devastating illness that can result in rapid death or have long-lasting repercussions for survivors and their families," said Andrin Oswald, CEO of Novartis Vaccines and Diagnostics. Through industry-leading scientific expertise, the company is focused on extending critical meningococcal vaccines research. The symptoms, which can include sudden onset of fever, rash, headache and stiff neck, can progress rapidly.
Five serogroups cause the majority of meningococcal disease worldwide: A, B, C, W-135 and Y[1]. Novartis Vaccines is the world's fifth-largest vaccines manufacturer and second-largest supplier of flu vaccines in the US. Novartis is the only company with leading positions in these areas.novartis.] Centers for Disease Control and Prevention.
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Serogroups B and C are predominant in Europe.”
The study protocol called for four groups of animals, two of which would be studied for 6 weeks to look at the acute effects of Lung ARS and the potential efficacy of AEOL 10150 as a countermeasure, and two which would be studied for six months to look at the chronic effects of Lung ARS and the potential efficacy of AEOL 10150 as a countermeasure. Twenty animals received a 40 mg loading dose of AEOL 10150 two hours after exposure and then received 20 mg of AEOL 10150 three times per week for four weeks.05) survival advantage, statistically significant differences in body weights and wet lung weights were seen over the first six weeks of the study.
About Aeolus Pharmaceuticals
Aeolus is developing a variety of therapeutic agents based on its proprietary small molecule catalytic antioxidants, with AEOL 10150 being the first to enter human clinical evaluation.
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